Combination treatment in metastatic prostate cancer: is the bar too high or have we fallen short?
- Author(s)
- Chen, K; O'Brien, J; McVey, A; Jenjitranant, P; Kelly, BD; Kasivisvanathan, V; Lawrentschuk, N; Murphy, DG; Azad, AA;
- Journal Title
- Nature Reviews Urology
- Publication Type
- Review
- Abstract
- Androgen deprivation therapy (ADT) alone has been the cornerstone of treatment for patients with newly diagnosed metastatic prostate cancer for the past century. Based on results from landmark trials in the past decade, combination approaches of ADT with chemotherapy or novel hormonal agents have established a new standard of care for these patients. This paradigm shift in treatment has been reflected in the updates to guideline recommendations of major professional associations. However, real-world data from around the world have highlighted the dismal adoption of combination therapy, despite evidence-based recommendations. The disparity between evidence and practice is concerning, especially with emerging evidence of survival benefit with further treatment intensification using triplet combinations (ADT, docetaxel and novel hormonal agents). Thus, a pressing need to raise awareness and call the uro-oncology community to action exists to deliver evidence-based care for these patients.
- Publisher
- Nature Portfolio
- Keywords
- Male; Humans; *Prostatic Neoplasms/drug therapy/pathology; Androgen Antagonists/therapeutic use; Docetaxel/therapeutic use; Combined Modality Therapy; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Treatment Outcome
- Department(s)
- Surgical Oncology; Medical Oncology
- PubMed ID
- 36509970
- Publisher's Version
- https://doi.org/10.1038/s41585-022-00669-z
- Open Access at Publisher's Site
https://doi.org/10.1038/s41585-022-00669-z- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-04-13 02:29:15
Last Modified: 2023-04-13 04:32:06